Cinnamaldehyde inhibits porcine coronaviruses infection by targeting HIF-1α

This mechanism not only effectively restricts PEDV replication but also exerts broad-spectrum antiviral activity against transmissible gastroenteritis virus (TGEV) and porcine respiratory coronavirus (PRCV). Importantly, In vivo experiments showed that CA inhibits PEDV replication in wild‑type (WT) mice, an effect that was abrogated in Ifnαr⁻/⁻ mice. Furthermore, CA restrains PEDV replication in piglets by abolishing HIF‑1α‑mediated inhibition of IFN responses.

This study first demonstrates that CA enhances IFN responses to inhibit porcine coronaviruses replication by lowering HIF‑1α-glycolysis pathway. It provides new candidate drugs for the prevention and control of PEDV and other porcine coronaviruses.