UniProt Pan-Proteomes 2026_02

UniProt Pan-Proteomes 2026_02<p dir="ltr">This is the Pan-Proteomes dataset published as part as UniProt release 2026_02 (10-Jun-2026).</p><p dir="ltr">It is the first release of the new UniProt Pan-Proteomes.</p><p dir="ltr">Please note that due to upload limitations, the original pp* subfolders have been replaced by a single compressed .tgz archive.</p><p dir="ltr">The latest version (published with each UniProt release) of the data set is <a href="ftp.uniprot.org/pub/databases/uniprot/current_release/knowledgebase/pan_proteomes/" target="_blank">available under UniProt FTP site</a>.</p><h2 dir="ltr">What are Pan-Proteomes?</h2><p dir="ltr">UniProt provides <a href="uniprot.org/help/pan_proteomes" target="_blank">Pan-Proteomes</a> at the species level to capture unique sequences absent from the <a href="uniprot.org/help/reference_proteome" target="_blank">reference proteome</a>, in order to reflect the proteome diversity of the species.

A pan-proteome is composed of a set of protein sequences, where each sequence represents a protein cluster from the analyzed proteomes of that species. A protein cluster is a group of similar protein sequences based on specified criteria, such as sequence identity and alignment coverage.</p>