Data · dataset · 2026
Acute thrombocytopenia with acetylsalicylic acid: a case report
Listed in ZivaHub and Deakin Research Online — shown once because both records carry DOI 10.6084/m9.figshare.34030151.v1
<p>Acetylsalicylic acid-associated thrombocytopenia is rare and has mainly been described in isolated case reports.
Description
We report a case of acute thrombocytopenia temporally associated with an acetylsalicylic acid-containing preparation in an elderly patient with multiple comorbidities.</p> <p>A 71-year-old woman developed abrupt thrombocytopenia during hospitalisation, with platelet counts decreasing from 338 × 10<sup>9</sup>/L to 25 × 10<sup>9</sup>/L without major bleeding manifestations.
Peripheral blood smear confirmed marked thrombocytopenia without platelet aggregation or schistocytes. The acetylsalicylic acid-containing preparation was discontinued, whereas Linagliptin treatment was continued. Platelet counts subsequently recovered and normalised during follow-up.
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Causality assessment using the Naranjo Adverse Drug Reaction Probability Scale supported a probable drug-related association.</p> <p>Previous reports have suggested possible immune-mediated and idiosyncratic mechanisms for acetylsalicylic acid-associated thrombocytopenia. Although alternative etiologies could not be completely excluded in the present case, the temporal relationship between drug exposure and platelet recovery after withdrawal supported a possible association.
Clinicians should remain aware that acetylsalicylic acid-containing preparations may potentially contribute to severe haematologic adverse events, particularly in elderly patients with multiple comorbidities and polypharmacy.</p>
Links
Where it is published
- DOI doi.org/10.6084/m9.figshare.34030151.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Bioinformatics and computational biology · Bioinformatics and computational biology · Cancer · Cancer · Chemistry · Chemistry · Earth & Environmental Science · Earth & Environmental Science · Genetics · Genetics · Immunology · Immunology · Infectious diseases · Infectious diseases · Life Sciences · Life Sciences · Medicine & Health · Medicine & Health · Research, science and technology policy · Research, science and technology policy
Provenance · 2 source records, 25 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34030151 | 11 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/34030151 | 11 d ago | JSON v1 |
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|---|---|---|---|
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| concepts[field].anzsrc:field:320211 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Infectious Diseases'] |
| concepts[field].anzsrc:field:320211 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Infectious Diseases'] |
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| concepts[field].anzsrc:group:3204 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
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| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
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| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |