Data for: "A robust SNP barcode for typing Mycobacterium tuberculosis complex strains"

Several systems have been proposed to classify MTBC samples into distinct lineages and families, using molecular genotypes (e.g. spoligotyping or MIRU-VNTR), regions of difference (RD) and single nucleotide polymorphisms (SNPs).

However, these systems lack accuracy or resolution due to the limited genetic variation studied or small number of samples used in their construction. We identified ~90k SNP across a global strain collection of 1,590 genomes. The SNP-based phylogeny was consistent with the gold-standard RD classification system and revealed fine-scale diversity.