Data · dataset · 2026
Identification and characterisation of a novel antimicrobial peptide from the defensive skin secretion of the Heilongjiang brown frog, Rana amurensis
Listed in ZivaHub and Deakin Research Online and DMU Figshare and UCL Research Data Repository — shown once because both records carry DOI 10.17034/32631816.v1
Antimicrobial peptides (AMPs) are one of the research hotspots because of the special mechanisms they have which make them less prone to inducing resistance.
Description
However, cytotoxicity limits the development of antimicrobial peptides. It has been proven that many structural parameters have important effects on the antimicrobial activity of the peptide.
So, an increasing number of researchers have begun to pay attention to the relationship of structure and activity of peptides. The amphibian skin secretion is a huge resource for AMPs. In this study, a novel AMP (QUB-2944) from the defensive skin secretion of the Heilongjiang Brown Frog, Rana amurensis, has been identified and characterised.
Read the rest (2 more)
The nucleotide sequence and opening-reading frame amino acid residues of the novel peptide QUB-2944 were obtained by the combination of molecular cloning and Sanger sequencing. Then bioactivity of the peptide was evaluated through using antimicrobial assays, antiproliferative assays and haemolysis assay. It was found to inhibit the growth of E. coli (MIC=2µM), S. aureus (MIC=16µM), and C. albicans (MIC=64µM).
It also possessed antiproliferative activity against NCI-H838 (IC50=4.123µM) and strong haemolytic activity (HC50=14.21 µM). The results showed that QUB-2944 is a brevinin-2 peptide, which has value to be further developed as a drug candidate in the future.<br><br><i>Thesis embargoed until 31 December 2026</i>.
Links
Where it is published
- DOI doi.org/10.17034/32631816.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science
- Inferred from text
- Sequencing 75%
Provenance · 4 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32631816 | 10 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32631816 | 10 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32631816 | 10 d ago | JSON v1 |
| UCL Research Data Repository | oai:figshare.com:article/32631816 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[modality].local:modality:sequencing | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |