Omics · study · 2026
Overcoming methicillin resistance in Staphylococcus aureus via metal ion disruption of bacterial metabolism
Listed in NCBI GEO
PBT2 is a zinc ionophore which demonstrates antibacterial activity as a standalone agent, and can be combined with conventional antibiotics to resensitise resistant pathogens to bactericidal killing.
Description
This study reports the impact of PBT2+Zn on on the transcriptome of S. aureus USA300-HO-MR, highlighting the global genetic changes in response to PBT2+Zn induced metal disruption, comprising Zn intoxication and Mn depletion.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301640 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301640 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1285867 ncbi.nlm.nih.gov/bioproject/PRJNA1285867 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
Provenance · 1 source records, 6 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE301640 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |