Omics · study · 2026
Conformational Dynamics in RNA Cleavage Specificity During Dicing
Listed in NCBI GEO
In this study, using massively parallel dicing assays and cryo-electron microscopy, we identify a previously unrecognized guanosine-favored (G-favored) binding pocket in DICER that exhibits a striking specificity for guanosine.
Description
This discovery fundamentally redefines the canonical view of DICER substrate recognition, as it contrasts with the known uridine-favored (U-favored) pocket, which binds uridine, adenine, and cytosine while excluding guanosine.
We demonstrate that these distinct G- and U-favored pockets govern the generation of 21-nt and 22-nt small RNAs, respectively, revealing a new layer of control in small RNA biogenesis
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE296nnn/GSE296721 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296721 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1260926 ncbi.nlm.nih.gov/bioproject/PRJNA1260926 ↗
project · from NCBI GEO
- PubMed 41781616 pubmed.ncbi.nlm.nih.gov/41781616 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Industrial biotechnology 71% · Microscopy 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE296721 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3106 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (71%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:microscopy | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |