Data · collection · 2015
The E3 ligase APC/C-Cdh1 regulates MEF2A-dependent transcription by targeting SUMO-specific protease 2 for ubiquitination and degradation
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Activity-dependent stimuli induced a calcineurin-mediated dephosphorylation of the transcriptional factor MEF2A at serine408 and promoted a switch from SUMOylation to acetylation at lysine403 which led to MEF2A transcriptional activation.
Description
We previously identified SENP2 is the de-SUMOylation enzyme for MEF2A and promotes MEF2A-dependent transcription. We report here a requirement for APC Cdh1 -SENP2-MEF2A axis in the regulation of MEF2A transcriptional activation.
APC Cdh1 interacts with and targets SENP2 for ubiquitination and destruction in the cytoplasm by recognizing a conserved canonical D-box motif in SENP2. Moreover, Cdh1 regulates the transcriptional activity of MEF2A in a SENP2 dependent manner. Activity-dependent stimuli prevented APC Cdh1 -induced SENP2 ubiquitination, promoted SENP2 nuclear accumulations, and caused MEF2A de-SUMOylation and MEF2A acetylation, leading to MEF2A transcriptional activation.
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Thus, our findings defined a post-transcriptional mechanism underlying activity-dependent stimuli-induced MEF2A transcriptional activation.
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- Repository landing page tandf.figshare.com/collections/The_E3_ligase_APC_C_Cdh1_regulates_MEF2A_dependent… ↗
landing page · from DataCite
- Repository landing page tandf.figshare.com/collections/The_E3_ligase_APC_C_Cdh1_regulates_MEF2A_dependent… ↗
landing page · from DataCite
- DOI doi.org/10.6084/m9.figshare.c.2030063 ↗
DOI / persistent id · from DataCite
- DOI doi.org/10.6084/m9.figshare.c.2030063.v1 ↗
DOI / persistent id · from DataCite
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Catalogue records · 4
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.c.2030063.v1 ↗
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- DataCite API api.datacite.org/dois/10.6084/m9.figshare.c.2030063 ↗
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- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.c.2030063.v1 ↗
catalogue entry · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.c.2030063 ↗
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Topics
- Stated by source
- Biological sciences · Biological sciences · Clinical medicine · Clinical medicine · Health sciences · Health sciences
- From keywords
- Bioinformatics and computational biology · Cancer · Cancer · Chemistry · Chemistry · Infectious diseases · Life Sciences · Life Sciences · Plant biology
Related
- Possibly the same asThe E3 ligase APC/C-Cdh1 regulates MEF2A-dependent transcription by targeting SUMO-specific protease 2 for ubiquitination and degradation
- Possibly the same asThe E3 ligase APC/C-Cdh1 regulates MEF2A-dependent transcription by targeting SUMO-specific protease 2 for ubiquitination and degradation
Provenance · 2 source records, 19 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.6084/m9.figshare.c.2030063 | 14 d ago | JSON v1 |
| DataCite | 10.6084/m9.figshare.c.2030063.v1 | 14 d ago | JSON v1 |
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|---|---|---|---|
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| concepts[disease].local:disease:cancer | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
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