Data · dataset · 2026
QUB-2577: A Bioactive Peptide from Pickerel Frog (Rana palustris) Skin Secretion
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32863040.v1
The skin of a frog is an important organ with a complex structure, which can play an important role not only in developing adaptation to the complex environment but also in preventing infection by microorganisms.
Description
Skin secretion of frogs contains a large number of antimicrobial peptides (AMPs) and they are considered as a promising source of antibiotic alternatives.<br>In this thesis, the peptide QUB-2577 was identified by "shotgun" cloning of precursor-encoding cDNA derived from the skin secretion of Rana palustris.
By applying solid-phase synthesis (SPPS), the peptide was synthesised. After purification, its antimicrobial, anticancer and other biological activities were examined. The QUB-2577 was found to process broad-spectrum antimicrobial activity.
Read the rest (1 more)
It can inhitbit the growth of Gram-negative bacteria E.coil (MIC = 32 µmol/L), Gram-positive bacteria S.aureus (MIC = 4 µmol/L), and the yeast C.albicans (MIC = 64 µmol/L). The QUB-2577 was also found to exhibit anticancer activity against U251-MG, H157, PC-3 cell lines at the concentration of 10-4 M, but the anticancer effect of the peptide decreased dramatically when the concentration was lower than 10-5 M. In the meantime, its haemolytic effect was found to be relatively high.
Links
Where it is published
- DOI doi.org/10.17034/32863040.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
Provenance · 3 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32863040 | 12 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32863040 | 12 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32863040 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |