Data · dataset · 2023
Replication Data for: Where Do Those Data Go? Reuse of screening results from clinical trials to estimate population prevalence of HBV infection in adults in Kilifi, Kenya
Listed in LSHTM Data Compass
This is a dataset summarising demographic, hepatitis B test results and alanine aminotransferase data from 6 completed different clinical trials conducted at KEMRI-Wellcome Trust Research Programme since 2016.
Description
The aim of this work was to give a seroprevalence estimate for HBV in Kilifi and also illustrate the amount of data that is likely available in this space that is currently underutilised. Data were accessed with permission from study PIs and from sponsors where necessary.
These data were standardised for age and sex using the Kilifi health and demographic surveillance system (KHDSS) data as the standard population structure. This data showed a crude HBsAg seroprevalence rate of 3.5%, which rose to 5% when standardised. There was considerable underrepresentation of women in these trials with 77% of participants being male.
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ALT was significantly higher in those who were HBsAg positive compared to negative, although was not outside the upper limit of normal for this population. We argue from these results that routine collection and collation of both blood borne virus prevalence and liver function test information will enable better modelling of not only blood borne viruses, but also for estimating the burden from liver disease across the African region.
This would be a low cost, efficient method that negates the need for the organisation of large sero-epidemiological surveys
Links
Where it is published
- DOI doi.org/10.7910/dvn/fpuh4r ↗
DOI / persistent id · from lshtm ac uk
Catalogue records · 1
- OAI-PMH record datacompass.lshtm.ac.uk/cgi/oai2?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3… ↗
metadata API · from lshtm ac uk
Topics
- From keywords
- Earth & Environmental Science · Humanities · Life Sciences · Medicine & Health · Social Science
- Inferred from text
- Disease 75% · Epidemiology 71%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| LSHTM Data Compass | oai:datacompass.lshtm.ac.uk:3726 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:disease | enrichment · lshtm ac uk | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:4202 | enrichment · lshtm ac uk | taxonomy-embedding@1.0.0 | title+keywords+description (71%) |
| concepts[field].local:field:earth-environmental | mapping · lshtm ac uk | connector:lshtm_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · lshtm ac uk | connector:lshtm_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · lshtm ac uk | connector:lshtm_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · lshtm ac uk | connector:lshtm_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · lshtm ac uk | connector:lshtm_ac_uk@1.0.0 | |
| description | source · lshtm ac uk | connector:lshtm_ac_uk@1.0.0 | /metadata/dc/description |
| publication_date | source · lshtm ac uk | connector:lshtm_ac_uk@1.0.0 | |
| title | source · lshtm ac uk | connector:lshtm_ac_uk@1.0.0 | /metadata/dc/title |