Table · dataset · 2026
Impact of genetic Sigma1 deficiency on development of status epilepticus and
Listed in figshare and Loughborough Research Repository — shown once because both records carry DOI 10.6084/m9.figshare.33966364.v1
<table><tr><td><p dir="ltr">Sigma-1 is an atypical receptor protein that modulates neuronal excitability and cellular stress responses, making it a promising target for epilepsy management.
Description
The intrahippocampal kainate model allows assessment of the impact of Sigma-1 deficiency on the induction of status epilepticus and the subsequent development of spontaneous recurrent seizures in wild-type in comparison to Sigma-1-knockout mice.
Kainate was slowly injected into the CA1 region of the right hippocampus under anesthesia and multimodal analgesia. During the same stereotactic surgical procedure, animals received a depth electrode implant in the CA1 region. The severity of induced status epilepticus was continuously monitored by electrographic recordings.
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To obtain additional information about behavioral and/or motor patterns (incl. immobility, head nodding, circling, and intermittent generalized convulsive seizures) during limbic status epilepticus, videos were recorded in parallel. During the following weeks, telemetric EEG recordings were conducted to assess the development of spontaneous recurrent seizures. The frequency and duration of electrographic seizures were determined.
Videos were recorded in parallel to capture occasional behavioral seizures.</p></td></tr></table><p></p>
Links
Where it is published
- DOI doi.org/10.6084/m9.figshare.33966364.v1 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
Topics
- From keywords
- Astronomy & Astrophysics · Basic pharmacology · Basic pharmacology · Central nervous system · Central nervous system · Chemistry · Chemistry · Clinical pharmacology and therapeutics · Clinical pharmacology and therapeutics · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Humanities · Humanities · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medicine & Health · Medicine & Health · Neurology and neuromuscular diseases · Neurology and neuromuscular diseases · Ocean & Atmospheric Science · Psychology & Behavioral Science · Social Science · Social Science
- Inferred from text
- Tabular 65%
Provenance · 2 source records, 37 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| figshare | oai:figshare.com:article/33966364 | 8 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/33966364 | 8 d ago | JSON v1 |
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|---|---|---|---|
| access_level | source · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].anzsrc:field:320903 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Central nervous system'] |
| concepts[field].anzsrc:field:320903 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Central nervous system'] |
| concepts[field].anzsrc:field:320905 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Neurology and neuromuscular diseases'] |
| concepts[field].anzsrc:field:320905 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Neurology and neuromuscular diseases'] |
| concepts[field].anzsrc:field:321401 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Basic pharmacology'] |
| concepts[field].anzsrc:field:321401 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Basic pharmacology'] |
| concepts[field].anzsrc:field:321402 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Clinical pharmacology and therapeutics'] |
| concepts[field].anzsrc:field:321402 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Clinical pharmacology and therapeutics'] |
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| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
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| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
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| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
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| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[modality].local:modality:tabular | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (65%) |
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| license | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/rights |
| publication_date | source · figshare com | connector:figshare_com@1.0.0 | |
| title | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/title |