Association of a Han Chinese urticaria-derived polygenic risk score with chronic spontaneous urticaria susceptibility and advanced systemic treatment use

<p>Chronic spontaneous urticaria (CSU) is a heterogeneous mast cell–driven disease with variable treatment needs, but the clinical relevance of Han Chinese urticaria-derived polygenic risk scores (PRSs) remains unclear.</p> <p>To evaluate the associations between Han Chinese urticaria-derived PRSs, CSU susceptibility, and advanced systemic treatment use.</p> <p>We conducted a retrospective case-control study using Taiwan Precision Medicine Initiative participants at Taichung Veterans General Hospital.

CSU cases and matched controls were identified using diagnostic codes and electronic medical records. Five urticaria-derived PRS models were evaluated using receiver operating characteristic curves (ROC). The best-performing PRS was categorized into quartiles, and logistic regression assessed associations with CSU susceptibility and advanced systemic treatment use.</p> <p>The study included 4,676 patients with CSU and 18,704 matched controls.