Plasma-mediated approaches for biomaterial surface modification

However, due to their hydrophobic properties, the clinical application of these devices is limited by associated problems of infection and tissue trauma upon implantation. Many methods have been developed for modifying surface properties, including wet chemicals, plasma treatment, etc. Plasma treatment, as an environmentally friendly method, can activate the surface of biomaterials, and modify the surface hydrophilicity without changing the bulk properties.

Moreover, robust hydrophilic coatings were developed on silicone after silane priming pre-treatment. Grafted hydrogel coatings offer much promise for reducing common issues of infection, pain, and tissue damage associated with the use of hydrophobic medical device materials. This study has demonstrated an effective method for producing a long-term stable hydrophilic hydrogel coating loaded with nalidixic acid on hydrophobic medical device materials with the reduction of bacterial adherence.<br><i><br>Thesis embargoed until 31st December 2027</i>