Table 1_Association of deep vein thrombosis with poststroke epilepsy after acute ischemic stroke: a multicenter retrospective cohort study.docx

DVT was associated with higher odds of PSE in the unadjusted analysis (OR, 1.93; 95% CI, 1.56–2.39), and the association remained similar after adjustment for demographic and vascular factors. After further adjustment for NIHSS score, cortical lobe involvement, and anterior and posterior circulation involvement, the association was substantially attenuated and no longer statistically significant (OR, 1.10; 95% CI, 0.86–1.39; P = 0.45).

Results were consistent across sensitivity analyses. Adding DVT to the clinical model did not improve discrimination (AUC, 0.879 vs. 0.879; DeLong P = 0.255), Brier score, calibration, or decision-curve net benefit.</p>Conclusions<p>The association between DVT and 1-year PSE was largely explained by stroke severity and lesion phenotype. DVT provided little incremental predictive information beyond established clinical characteristics, supporting its interpretation as a marker of a more severe and clinically complex poststroke phenotype rather than an independent PSE risk factor.</p>