Data · collection · 2016
Understanding the efficacy of N,N -dimethylformamide and oxalyl chloride combination as chemoselective O -formylating agent: An unified experimental and theoretical study
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We have developed a simple but efficient synthetic protocol for the O- formylation of a wide range of aromatic hydroxyl/phenolic substrates using an N,N -dimethylformamide (DMF) and oxalyl chloride [(COCl) 2 ] combination in dichloromethane (DCM) as solvent at ambient temperature.
Description
The DMF/(COCl) 2 combination was found to be highly chemoselective for the aromatic/phenolic hydroxyl group over aliphatic hydroxyl or aromatic amine/thiol groups.
This chemoselectivity of DMF/(COCl) 2 combination towards O- formylation of aromatic alcohols was explained on the basis of outcomes of both experimental and density functional theory–based theoretical studies.
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Where it is published
- Repository landing page figshare.com/collections/Understanding_the_Efficacy_of_i_N_N_i_dimethylform… ↗
landing page · from DataCite
- DOI doi.org/10.6084/m9.figshare.c.2861755.v2 ↗
DOI / persistent id · from DataCite
Documentation and papers
- CC-BY creativecommons.org/licenses/by/3.0/us ↗
license · from DataCite
Catalogue records · 2
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.c.2861755.v2 ↗
metadata API · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.c.2861755.v2 ↗
catalogue entry · from DataCite
Topics
- Stated by source
- Biological sciences · Chemical sciences · Earth and related environmental sciences · Physical sciences
- Inferred from text
- Density functional theory 75% · Organic chemical synthesis 77%
Related
Provenance · 1 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.6084/m9.figshare.c.2861755.v2 | 13 d ago | JSON v1 |
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| concepts[field].fos:chemical-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:earth-and-related-environmental-sciences | source · DataCite | connector:datacite@1.0.0 | |
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