Mendelian randomization study of the causal association between peripheral blood cell levels and IgA nephropathy

Methods

Single nucleotide polymorphisms related to total white blood cells, neutrophils, monocytes, basophils, eosinophils, and lymphocytes and summary level genetic data related to IgAN were obtained from published genome-wide association studies. The inverse variance weighting method was used for two-sample Mendelian randomization analysis. At the same time, MR-PRESSO and MR-Egger were used to detect pleiotropic effects, and sensitivity analysis was performed by 'leave-one-out ' method.Results In the study of the effect of peripheral blood cell level on IgAN, the IVW method showed that total white blood cells, neutrophils and eosinophils as risk factors were causally associated with the risk of IgAN.