Structure · collection · 2018
FGF2 Enhances Odontoblast Differentiation by αSMA + Progenitors In Vivo
Listed in DataCite
The goal of this study was to examine the effects of early and limited exposure of perivascular cells expressing α (αSMA) to fibroblast growth factor 2 (FGF2) in vivo.
Description
We performed in vivo fate mapping by inducible Cre-loxP and experimental pulp injury in molars to induce reparative dentinogenesis. Our results demonstrate that early delivery of exogenous FGF2 to exposed pulp led to proliferative expansion of αSMA-tdTomato + cells and their accelerated differentiation into odontoblasts.
In vivo lineage-tracing experiments showed that the calcified bridge/reparative dentin in FGF2-treated pulps were lined with an increased number of Dspp + odontoblasts and devoid of BSP + osteoblasts. The increased number of odontoblasts derived from αSMA-tdTomato + cells and the formation of reparative dentin devoid of osteoblasts provide in vivo evidence for the stimulatory effects of FGF signaling on odontoblast differentiation from early progenitors in dental pulp.
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Where it is published
- Repository landing page figshare.com/collections/FGF2_Enhances_Odontoblast_Differentiation_by_SMA_s… ↗
landing page · from DataCite
- DOI doi.org/10.25384/sage.c.4068926 ↗
DOI / persistent id · from DataCite
Documentation and papers
- CC BY 4.0 creativecommons.org/licenses/by/4.0 ↗
license · from DataCite
- IsSupplementTo 10.1177/0022034518769827 doi.org/10.1177/0022034518769827 ↗
publication · from DataCite
Catalogue records · 2
- DataCite API api.datacite.org/dois/10.25384/sage.c.4068926 ↗
metadata API · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.25384/sage.c.4068926 ↗
catalogue entry · from DataCite
Topics
- Stated by source
- Clinical medicine · Materials engineering
- Inferred from text
- Dentistry 71%
Related
- Inverse of same asFGF2 Enhances Odontoblast Differentiation by αSMA + Progenitors In Vivo
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.25384/sage.c.4068926 | 13 d ago | JSON v1 |
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|---|---|---|---|
| access_level | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| concepts[field].anzsrc:group:3203 | enrichment · DataCite | taxonomy-embedding@1.1.0 | title+keywords+description (71%) |
| concepts[field].fos:clinical-medicine | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:materials-engineering | source · DataCite | connector:datacite@1.0.0 | |
| created_date | source · DataCite | connector:datacite@1.0.0 | |
| description | source · DataCite | connector:datacite@1.0.0 | /data/attributes/descriptions |
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| publication_date | source · DataCite | connector:datacite@1.0.0 | /data/attributes/dates |
| title | source · DataCite | connector:datacite@1.0.0 | /data/attributes/titles/0/title |
| updated_date | source · DataCite | connector:datacite@1.0.0 |