Data · dataset · 2025
Evaluation of simvastatin activity in the mevalonate pathway in Staphylococcus aureus
Listed in REDU - Unicamp Institutional Research Data Repository
This study investigated the antimicrobial mechanism of simvastatin, a cholesterol-lowering drug that has shown in vitro activity against Staphylococcus aureus.
Description
The focus was on the bacterial HMG-CoA reductase, a enzyme player in the mevalonate pathway. The enzyme from S. aureus was cloned, expressed in E. coli, and purified for enzymatic assays.
Molecular modeling studies were performed using AlphaFold 3 and molecular docking to explore the interaction between simvastatin and the active site of the bacterial enzyme.
Links
Where it is published
- Dataverse dataset page redu.unicamp.br/dataset.xhtml?persistentId=doi%3A10.25824%2Fredu%2FKNWSFL ↗
landing page · from redu unicamp br
- DOI doi.org/10.25824/redu/knwsfl ↗
DOI / persistent id · from redu unicamp br
Catalogue records · 1
- Dataverse API redu.unicamp.br/api/datasets/:persistentId/?persistentId=doi%3A10.25824%2Fredu… ↗
metadata API · from redu unicamp br
Topics
- Stated by source
- Medicine, Health and Life Sciences
- From keywords
- Life Sciences · Medicine & Health
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| REDU - Unicamp Institutional Research Data Repository | doi:10.25824/redu/KNWSFL | 8 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].dataverse_subject:medicine-health-and-life-sciences | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 | /subjects |
| concepts[field].local:field:life-sciences | mapping · redu unicamp br | connector:redu_unicamp_br@1.0.0 | /subjects |
| concepts[field].local:field:medicine-health | mapping · redu unicamp br | connector:redu_unicamp_br@1.0.0 | /subjects |
| created_date | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 | |
| description | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 | /description |
| publication_date | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 | |
| title | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 | /name |
| updated_date | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 | |
| version_label | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 |