Data · dataset · 2026
β-D-N4-Hydroxycytidine inhibits canine parvovirus type 2 replication through transition-biased mutagenesis
Listed in ScienceDB
Description
Canine parvovirus type 2 (CPV-2) causes severe disease in young dogs, yet no specific antiviral therapy is currently available. β-D-N4-hydroxycytidine (NHC) is a nucleoside analogue which can perform broad-spectrum antiviral activities against RNA viruses, but its activity against DNA viruses remains poorly characterized. Here, we evaluated the antiviral activity and potential mechanism of NHC against CPV-2 in vitro.
NHC dose-dependently inhibited CPV-2a, CPV-2b, and CPV-2c replication in F81 cells with limited cytotoxicity.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.42865 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Disease 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.42865 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |