Data · dataset · 2026
QUB-2410: a bioactive peptide from the skin secretion of the south American orange-legged leaf frog (phyllomedusa hypochondrialis)
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32867099.v1
As a consequence of the widespread use of antimicrobial agents, not only in the clinic but also in agriculture, veterinary medicine and even animal husbandry, antibiotic resistance emerged and gradually became one of the most evident crises during the past several decades.
Description
Antimicrobial peptides (AMPs) now represent an important alternative strategy for treating antibiotic resistance as well as a new source of potential anticancer drugs, thus these peptides have been attracting increased research attention.
The skin secretions of amphibians contain abundant peptides and most of these have pronounced bioactivities.<br>In this thesis, a bioactive peptide named QUB-2410 was successfully identified from the venom of the skin of the South American orange-legged leaf frog (Phyllomedusa hypocondrialis) by “shotgun” cloning. This peptide was then synthesised using solid-phase peptide synthesis and then analysed by HPLC and MALDI-TOF MS to determine the purity and authenticity of the molecular mass.
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The results showed that the chemically synthesized peptides exhibited strong antibacterial activity against E. coli, S. aureus and C. albicans with minimum inhibitory concentration(MIC) values of 8 µM, 8 µM and 32 µM, respectively. Additionally, QUB-2410 failed to inhibit the proliferation of cancer cells against PC-3, H157, U251MG and MCF-7 at the concentration of 10-5 M. Moreover, QUB-2410 also showed relatively weak haemolytic activity.
QUB 2410 may have the potential to be developed into a novel antibiotic drug.
Links
Where it is published
- DOI doi.org/10.17034/32867099.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science
- Inferred from text
- Cancer 75%
Provenance · 3 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32867099 | 11 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32867099 | 11 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32867099 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |