Mitochondrial DNA Haplogroup A may confer a genetic susceptibility to AIDS group from Southwest China

Thus, to illustrate the maternal genetic structure and further identify whether mtDNA variation(s) can effect HIV infection among southwest Chinese AIDS group, the whole mtDNA control region sequences of 70 AIDS patients and 480 health individuals from southwest China were analyzed here.

Our results indicated the plausible recent genetic admixture results of AIDS group; comparison of matrilineal components between AIDS and matched Han groups showed that mtDNA haplogroup A ( p = 0.048, OR = 3.006, 95% CI = 1.109–8.145) has a significant higher difference between the two groups; further comparison illustrated that mtDNA mutations 16,209 ( p = 0.046, OR = 2.607, 95% CI = 0.988–6.876) and 16,319 ( p = 0.009, OR = 2.965, 95% CI = 1.278–6.876) have significant differences between AIDS and matched control groups, and both of which were the defining variations of mtDNA haplogroup A, they further confirmed that mtDNA haplogroup A may confer genetic susceptibility to AIDS.