Omics · study · 2026
DMEM and EMEM as alternate growth media for pathogenic Leptospira
Listed in NCBI GEO
Pathogenic Leptospira spp. must adapt to diverse environments during their life cycle, yet most laboratory studies rely on in vitro culture conditions that poorly reflect the host environment.
Description
This limitation restricts the relevance of transcriptomic studies for understanding leptospiral pathogenesis. In this study, we evaluated genome-wide gene expression of Leptospira interrogans grown in four different in vitro media—EMJH, DMEM, EMEM, and HAN—and compared their transcriptomic profiles to those obtained from bacteria recovered from the whole blood of infected hamsters.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297028 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297028 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1262408 ncbi.nlm.nih.gov/bioproject/PRJNA1262408 ↗
project · from NCBI GEO
- PubMed 39896660 pubmed.ncbi.nlm.nih.gov/39896660 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
Provenance · 1 source records, 6 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE297028 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |