Machine-learning guided discovery of emergent antimicrobial activity from dynamic covalent assemblies (<i>Streptococcus mutans</i>, RNA seq)

<p dir="ltr"><i>This dataset contains bulk RNA-seq data from Streptococcus mutans under three conditions: PBS control, A5B5 treatment for 0.5 h at a sub-MIC concentration, and A5B5 treatment for 4 h, with three biological replicates per condition (nine samples in total). counts_anno.csv and FPKM_anno.csv each contain all nine samples in a single annotated gene-expression matrix. The matrices include 1,850 gene identifiers present in both source datasets.

CTL-1/2/3 are PBS controls, A5B5-1/2/3 are the 4-h samples, and A5B5_0.5h-1/2/3 are the 0.5-h samples. The sample groups and original identifiers are provided in sample_metadata.csv.</i></p><p dir="ltr"><br></p><p dir="ltr">Methods documented for the original samples: Total RNA was extracted using the RNAprep Pure Cell/Bacteria Kit (TIANGEN, Beijing, China; Cat. No. DP430) according to the manufacturer’s protocol.