Data · dataset · 2026
A CANCER-TO-MACROPHAGE METABOLIC CIRCUIT SHAPES IMMUNOSUPPRESSION IN CCRCC
Listed in ScienceDB
Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of kidney cancer and is characterized by profound metabolic reprogramming and a highly immunosuppressive tumor microenvironment.
Description
Although immune checkpoint blockade (ICB) has substantially improved the treatment of advanced ccRCC, only a subset of patients achieve durable clinical benefit, while primary and acquired resistance remain major therapeutic challenges.
Increasing evidence suggests that tumor-intrinsic metabolic alterations not only support cancer cell growth and survival but also profoundly influence the composition and functional state of surrounding immune cells. However, the metabolic determinants that coordinate tumor–immune communication and contribute to immunotherapy resistance in ccRCC remain incompletely understood.Lipid metabolic reprogramming is a prominent feature of ccRCC and is closely associated with tumor progression and immune regulation.
Read the rest (2 more)
Alterations in phospholipid synthesis, remodeling, and intercellular lipid transfer may provide an important mechanism through which malignant cells reshape the tumor immune microenvironment. To identify metabolic regulators involved in ccRCC progression and antitumor immunity, we performed an in vivo CRISPR/Cas9 screening strategy and identified lysophosphatidylcholine acyltransferase 3 (LPCAT3) as a candidate regulator associated with tumor growth and therapeutic response.
LPCAT3 is markedly upregulated in ccRCC and its elevated expression is associated with unfavorable clinical outcomes.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.012nf ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.012nf | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license_text | source · scidb cn | connector:scidb_cn@1.0.0 | |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |