Data · dataset · 2026
Analysis of hypoxia-inducible factors in the deep-sea fish reveals genetic adaptation to hypoxic environments
Listed in ScienceDB
Oxygen levels in the ocean have decreased worldwide as a result of climate change and nutrient contamination, which has had a significant impact on marine ecosystems.
Description
Though deep-sea fish that reside in oxygen minimum zones (OMZs) demonstrate remarkable adaptations to hypoxia, the molecular mechanisms that underlie their resilience are still inadequately understood. The hypoxia-inducible factors (HIFs), regulated by the hypoxia signaling pathway, play a crucial role in maintaining cellular and systemic oxygen homeostasis in response to changes in oxygen supply.
In this study, we investigate the HIFs pathway in three deep-sea fish species: Pseudoliparis swirei, Ilyophis sp., and Liparis tanakai. We found that Ilyophis sp. HIF-1α shows stronger transcriptional activity and upregulates hypoxia-response genes more efficiently than other species.
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Mutational analysis revealed that the deletion mutation of the nuclear export signal (NES) in Ilyophis sp. HIF-1α may enhance its stability, while Plk3 may function as a negative regulator of deep-sea fish HIF-1α under hypoxic conditions. This study reveals divergent evolutionary strategies in hypoxia adaptation among deep-sea fishes, highlighting how structural and regulatory mechanisms enable survival in oxygen-deprived environments, and provides novel insights into the genetic mechanisms enabling survival in OMZs, advancing our understanding of marine hypoxia resilience and its implications for ecosystem dynamics under global deoxygenation.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.28860 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Ocean & Atmospheric Science · Social Science
- Inferred from text
- Fisheries sciences 74%
Provenance · 1 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.28860 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].anzsrc:group:3005 | enrichment · scidb cn | taxonomy-embedding@1.0.0 | title+keywords+description (74%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license_text | source · scidb cn | connector:scidb_cn@1.0.0 | |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |