Data · study · 2026
A Multi-Gene Signature Predicting 1-Year Survival in Stage I Liver Cancer: Integration of Preclinical and TCGA Data
Listed in NCBI GEO
This study used the Long Evans Cinnamon (LEC) rat model of Wilson's Disease and Hepatocellular Carcinoma (HCC), along with data from The Cancer Genome Atlas (TCGA) human database, to create a novel biomarker panel.
Description
We generated and analyzed a rat microarray gene expression profile by comparing liver tumor tissues with adjacent normal tissues from the same animals, covering approximately 30,000 genes. The microarray results were translated into a five-gene panel that predicts 1-year survival probability in Stage I liver cancer patients using TCGA data in combination with machine learning and bioinformatics approaches.
The 5-year panel of five genes demonstrated robust performance throughout validation, particularly in predicting 1-year survival in Stage I patients.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE309nnn/GSE309883 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309883 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1363936 ncbi.nlm.nih.gov/bioproject/PRJNA1363936 ↗
project · from NCBI GEO
- PubMed 41751400 pubmed.ncbi.nlm.nih.gov/41751400 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Rattus norvegicus
- From keywords
- Life Sciences
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE309883 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (71%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |