Omics · study · 2026
Maternal exposure to air pollution alters the postnatal metabolic response to ozone in peri-adolescent offspring.
Listed in NCBI GEO
Exposure to environmental pollutants during key stages of development increases the risk of disease later in life.
Description
One such toxicant with growing evidence of this response is the air pollutant, ozone. Exposure to ozone during the implantation receptivity period in rats affects the metabolic status of offspring at adolescence, which may increase their susceptibility to subsequent environmental exposures.
Herein, we studied the impacts of maternal ozone exposure on postnatal systemic responses to ozone in male and female offspring. Following peri-implantation ozone exposure (0.8 ppm for 4 hours/day on gestation days 5 and 6), offspring were exposed to ozone for 1 day/week on postnatal weeks 5–7. After the final exposure, metabolic effects were analyzed by circulating hormones and clinical chemistries, as well as hepatic lipid status and transcriptomic alterations.
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By and large, male offspring from ozone-exposed dams were more greatly impacted than those from air-exposed dams. This included increased hepatic lipid mobilization, increased circulating glucose, and a robust number of differentially expressed genes (2,348). Interestingly, many of these transcriptomic differences were attributed to maternal ozone exposure, with 1,741 of these genes sharing directional similarity with postnatally exposed air littermates.
Females, on the other hand, reported minimal baseline effects of maternal ozone exposure (108). However, postnatal ozone exposure in female offspring substantially increased these differences to 947 genes. Collectively, this work supports the growing evidence that early pregnancy exposure to ozone alters the metabolic development of the offspring.
Furthermore, postnatal exposure to environmental stressors reveals hepatic susceptibilities that are sexually dimorphic.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313406 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313406 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1379455 ncbi.nlm.nih.gov/bioproject/PRJNA1379455 ↗
project · from NCBI GEO
- PubMed 41580963 pubmed.ncbi.nlm.nih.gov/41580963 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE313406 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |