Synovial transcriptomic response to intra-articular 2.5% polyacrylamide hydrogel in equine experimental osteoarthritis [RNAseq_SF]

Despite this high prevalence, no approved pharmacological intervention, biological therapy, or procedure prevents or reverses progressive destruction of degenerative joints. Intra-articular injectable polyacrylamide hydrogels (iPAAG), which consist of biocompatible non-degradable synthetic polymers, have been introduced with reported clinical efficacy.

However, their potential mechanisms of action have not been fully investigated. Objectives – To determine differential gene expression in synovial tissues following intra-articular injection of 2.5% iPAAG in experimentally induced equine OA. Study Design – Prospective randomized placebo-controlled longitudinal cohort study.