The association of wildfire smoke with respiratory and cardiovascular emergency department visits in Colorado in 2012: A case crossover study

The goal of this study was to investigate the relationship of local PM₂.₠levels, modeled using the Weather Research and Forecasting Model with Chemistry, with emergency department visits and acute hospitalizations for respiratory and cardiovascular outcomes during the 2012 Colorado wildfires. Conditional logistic regression was used to assess the relationship between both continuous and categorical PM₂.₠and emergency department visits during the wildfire period, from June 5th to July 6th 2012.

For respiratory outcomes, we observed positive relationships between lag 0 PM₂.₠and asthma/wheeze (1 h max OR 1.01, 95 % CI (1.00, 1.01) per 10 μg/m³; 24 h mean OR 1.04 95 % CI (1.02, 1.06) per 5 μg/m³), and COPD (1 h max OR 1.01 95 % CI (1.00, 1.02) per 10 μg/m³; 24 h mean OR 1.05 95 % CI (1.02, 1.08) per 5 μg/m³). These associations were also positive for 2-day and 3-day moving average lag periods. When PM₂.₠was modeled as a categorical variable, bronchitis also showed elevated effect estimates over the referent groups for lag 0 24 h average concentration.