Omics · study · 2026
Comprehensive transcriptome analysis of influenza A virus-infected MDCK cells treated with Mel56
Listed in NCBI GEO
To identify the genes involved in the anti-influenza activity of Mel56, we performed an RNA sequencing (RNA-seq) analysis of IAV-infected MDCK cells treated with Mel56.
Description
A total of 1,767 differentially expressed genes (DEGs) were identified using |fold-change (FC)| ≥ 2 and raw p-value < 0.05 as thresholds for the comparison between Mel56-treated and DMSO-treated MDCK cells infected with A/PR/8/34 virus. Among these DEGs, 1,062 were upregulated and 705 were downregulated (≥2-FC) in response to Mel56 treatment.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304376 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304376 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1301129 ncbi.nlm.nih.gov/bioproject/PRJNA1301129 ↗
project · from NCBI GEO
- PubMed 42138434 pubmed.ncbi.nlm.nih.gov/42138434 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE304376 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |