Data · dataset · 2026
Discovery of novel antimicrobial agents and resistance mechanisms in Halophilic Archaea
Listed in ZivaHub and Deakin Research Online and DMU Figshare and UCL Research Data Repository — shown once because both records carry DOI 10.17034/32632968.v1
This work aimed to examine whether halophilic archaea may act as a reservoir for antimicrobial resistance genes in extreme environments and their potential to be a source of new antimicrobial agents.
Description
The extremely halophilic archaea Halorubrum saccharovorum CSM-52, isolated from Kilroot salt mine in Northern Ireland, was investigated for the presence of resistance mechanisms, specifically active efflux pumps and the potential of the involvement of these pumps in their innate resistance to antimicrobials.
Separately, H. saccharovorum was serially exposed to sublethal concentrations of ciprofloxacin in order to examine its adaptive response and ability to develop antibiotic resistance under antimicrobial stress. The metagenome of stalactite structures formed within the Triassic halite of Kilroot salt mine were subjected to metagenomic mining using a novel bioinformatic pipeline, AMPLY, for the discovery antimicrobial peptide sequences within this unique environment.
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The top hit sequences were synthesized and examined for their antimicrobial activity against clinically relevant bacteria, Candida albicans and representative haloarchaea.<br><br><i>Thesis embargoed until 31 July 2027</i>.
Links
Where it is published
- DOI doi.org/10.17034/32632968.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Life Sciences · Life Sciences · Life Sciences · Life Sciences
- Inferred from text
- Evolutionary biology 72%
Provenance · 4 source records, 14 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32632968 | 12 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32632968 | 12 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32632968 | 12 d ago | JSON v1 |
| UCL Research Data Repository | oai:figshare.com:article/32632968 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].anzsrc:group:3104 | enrichment · zivahub uct ac za | taxonomy-embedding@1.1.0 | title+keywords+description (72%) |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |