Structure · dataset · 2019
In vivo optical performance of near infrared-emitting borylated polyfluorene-alt-benzothiadiazoles embedded within biodegradable PEG-PLGA nanoparticles
Listed in Teesside University Research Data Repository
Borylated polyfluorene-benzothiadiazoles (PF8-BT) are π-conjugated polymers (CPs) with deep-red/near infrared (NIR) absorption and emission profiles suitable for in vivo optical imaging.
Description
A fully borylated PF8-BT derivative (P4) was encapsulated in PEG-PLGA nanoparticles and compared with a reference NIR-emitting CP (PCPDTBT) or indocyanine green (ICG). All formulations satisfied quality requirements for parenterally administered diagnostics.
P4 nanoparticles had higher quantum yield (2.3%) than PCPCDTBT (0.01%) or ICG nanoparticles (1.1%). The signal:background ratios (SBR) of CP systems, P4 and PCPDTBT in a phantom mouse (λem=820 nm) increased linearly with fluorophore mass (12.5-100 µg/mL), while the SBR of ICG decreased above 25 µg/mL. P4 nanoparticles experienced < 10% photobleaching over 10 irradiations (PCPDTBT: ~25% and ICG: > 44%).
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In a mouse tumour xenograft model, P4 nanoparticles showed a 5-fold higher SBR than PCPDTBT particles with fluorophore accumulation in the liver > spleen > tumour. Blood chemistry and tissue histology showed no abnormalities compared to untreated animals after a single administration
Links
Where it is published
- DOI doi.org/10.17632/2vn868fb9j.1 ↗
DOI / persistent id · from researchdata tees ac uk
Catalogue records · 1
- OAI-PMH record data.mendeley.com/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Adata… ↗
metadata API · from researchdata tees ac uk
Topics
- From keywords
- Earth & Environmental Science · Materials Science
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Teesside University Research Data Repository | oai:data.mendeley.com/2vn868fb9j.1 | 20 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · researchdata tees ac uk | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:earth-environmental | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[modality].local:modality:imaging | enrichment · researchdata tees ac uk | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| title | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/title |