Supplementary file 1_Diagnostic value of left atrial three-dimensional strain for paroxysmal atrial fibrillation in patients with acute ischemic stroke.docx

Objective<p>To investigate the diagnostic and incremental value of left atrial three-dimensional (3D) strain parameters for paroxysmal atrial fibrillation (PAF) detected by short-term in-hospital cardiac monitoring and early Holter recording in patients with acute ischemic stroke (AIS).</p>Methods<p>A total of 340 consecutive AIS patients were enrolled and divided into non-PAF (n = 282) and PAF (n = 58) groups. A base diagnostic model was constructed using univariable logistic regression and least absolute shrinkage and selection operator (LASSO) regression.

The optimal 3D strain parameter was selected via receiver operating characteristic (ROC) curve analysis and added to the base model. Incremental value was assessed using C-index, net reclassification improvement (NRI), integrated discrimination improvement (IDI), and decision curve analysis (DCA). Model robustness was validated with bootstrap resampling.</p>Results<p>All 3D left atrial strain parameters showed diagnostic value for PAF [all area under the curve (AUC) > 0.6].