Population-based investigations into risk factors and surveillance strategies for endometrial hyperplasia and endometrial cancer

Accurate histopathological diagnosis is critical, as misclassification can lead to unnecessary procedures or inappropriate treatments. This thesis includes a systematic review addressing interobserver variation among pathologists, exploring how differences in diagnostic practices may affect diagnostic consistency.</p> <p>Additionally, two population-level studies were conducted that linked data from the Northern Ireland Endometrial Hyperplasia Register with the Northern Ireland Cancer Registry.

These studies examined the relationship between endometrial hyperplasia and endometrial cancer, including whether prior hyperplasia diagnoses are associated with improved survival outcomes in endometrial cancer patients, as well as the prevalence of concurrent endometrial cancer diagnoses in individuals with both endometrial hyperplasia and cancer. Using UK Biobank data, this thesis also investigated the potential role of multimorbidity in influencing endometrial cancer risk, given that the presence of multiple chronic conditions may alter disease susceptibility and impact overall health outcomes, thereby potentially contributing to an increased risk of cancer development.</p>Overall, these studies aimed to contribute to improving the diagnosis, surveillance, and prevention strategies for endometrial hyperplasia and endometrial cancer.<br><br><i>Thesis is embargoed until 31 July 2028</i><br>