Data Sheet 1_Incremental effect and risk association of obstructive coronary artery disease on microvascular myocardial ischemia in T2DM patients evaluated via CT myocardial perfusion.docx

Our investigation focused on assessing the impact of OCAD on MMI and delineating the prognostic relevance of MMI.</p>Methods<p>This study included four groups: (1) control group without OCAD (n = 125), (2) control group with OCAD (n = 99); (3) T2DM patients without OCAD (n = 100); (4) T2DM patients with OCAD (n = 93).

All patients received dynamic computed tomography myocardial perfusion imaging (CT–MPI) as well as coronary computed tomography angiography (CCTA). Univariate and multivariate linear regression analyses were performed to identify independent determinants of clinical characteristics and perfusion metrics related to MMI. Major adverse cardiovascular events (MACEs) were documented, and the prognostic significance of CT–MPI compared with clinical variables was assessed.</p>Results<p>The myocardial blood flow (MBF) stepwise reduced from the control (OCAD−), T2DM (OCAD−), control (OCAD+) to T2DM (OCAD+) group (p < 0.05).