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Data · dataset · 2022

VarDB2.0 - a proteogenomics database

Listed in Teesside University Research Data Repository

This VarDB2.0 database contains variant peptide sequences from COSMIC mutation, non-synonymous SNPs, three frame translated lncRNA and Pseudogenes.

Description

The database is used in the following paper, please cite the paper if it contributes your work: Rong Xiang, Leyao Ma, Mingyu Yang, Zetian Zheng, XiaoFang Cheng, Fujian Jia, Fanfan Xie, Fuqiang Li, Kui Wu, Yafeng Zhu*. Increased expression of peptides from non-coding genes in cancer proteomics datasets suggests potential tumor neoantigens.

Communications Biology. April 2021. File information: VarDB2.gtf - a GTF format contains genomics coordinates for corresponding transcripts included in VarDB2.0 VarDB2.zip - a zipped fasta format for VarDB2.fasta variant peptide sequences.

Read the rest (3 more)

CanProVar_peptide.fa.txt.zip - a zipped fasta format for variant peptides from CanProVar DB.

Note

CanProVar_peptide.fa is already included in VarDB2.fasta. e.g. variant peptide from non-synonymous SNPs >CanProVar_rs6673641_ZMYM6_P134S_missense_15 CITRHSSPACLPPPSKK the last integer "_15" in the header indicates the position of substituted amino acid in the peptide sequence. "P134S" indicates the position of substituted amino acid in the protein sequence. e.g. variant peptide from COSMIC mutation >COSMIC:ENST00000342988:SMAD4:p.K519E:Substitution-Missense:4 the last integer "4" in the header indicates the position of substituted amino acid in the peptide sequence. "p.K519E" indicates the position of substituted amino acid in the protein sequence. e.g. variant peptide from three frame translated Pseudogenes. >PGOHUM_ENST00000359512.8_PAR_Y_WASH6P_RF2 "RF2" indicates it is translated from the seconding reading frame (starting from second nucleotide) of its transcript with stop codon allowed in the middle. e.g. variant peptide from three frame translated lncRNA. >lncRNA_lnc-MLKL-27:11_RF2 "RF2" indicates it is translated from the seconding reading frame (starting from second nucleotide) of its transcript with stop codon allowed in the middle.

Links

Where it is published

Catalogue records · 1

Topics

Inferred from text
Cancer 75% · Genetics 72%
Provenance · 1 source records, 13 field assertions
SourceKeyLast seenRaw
Teesside University Research Data Repositoryoai:data.mendeley.com/kdfjcyz5z2.19 d agoJSON v1
FieldAssertionExtractorEvidence
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concepts[disease].local:disease:cancerenrichment · researchdata tees ac ukkeyword-concept-rules@1.0.0title+description (75%)
concepts[field].anzsrc:group:3105enrichment · researchdata tees ac uktaxonomy-embedding@1.0.0title+keywords+description (72%)
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concepts[field].local:field:social-sciencemapping · researchdata tees ac ukconnector:researchdata_tees_ac_uk@1.0.0
concepts[modality].local:modality:mass-spectrometrymapping · researchdata tees ac ukvocabulary-mapper@1.0.0keywords['Proteomics']
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