Data for: Effect of corticosterone on the gene expression in the context of global hippocampal transcription.

The problem is further exaggerated by underrepresentation of chronic experiments and interpretation of differentially expressed genes without understanding their contribution to the total transcriptomic activity. To fill existing gaps in knowledge we have performed a large transcriptomic experiment (48 mice in total), testing effects of prolonged treatment with corticosterone (5, 14 and 28 days) on hippocampal transcriptome (RNA sequencing).

The experiment showed that prolonged treatment with the corticosterone induced a set of transcriptomic effects that were replicable across treatment durations including genes relevant for human PTSD (Opalin, Pllp, Ttyh2, Lpar1) and prolonged stress in animals (Cnp, Fam163a, Fcrls, Tmem125). Some of affected genes are specific for oligodendrocytes, neurons, astrocytes, immune cells, vascular system and brain ventricles, indicating that glucocorticoids may affect all components of the central nervous system.