Data Sheet 1_Accelerometer-measured physical activity and risk of incident ulcerative colitis: a population-based prospective study.docx

Physical activity (PA) is promising, yet studies using self-reported data show inconsistent results. We examined the association between accelerometer-measured physical activity and UC risk in a large prospective cohort.</p>Methods<p>This cohort study analyzed data from 95,197 UK Biobank participants without baseline inflammatory bowel disease and with valid accelerometer data, with follow-up from 2013 to 2015 through 2023.

Machine learning models estimated time spent in sedentary behavior, light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA). MVPA patterns were categorized as active weekend warriors (≥231.5 min/week, ≥50% in 1–2 days), active regular (≥231.5 min/week, not meeting weekend warrior criteria), and inactive (<231.5 min/week). Cox proportional hazards regression assessed associations between PA and UC risk.</p>Results<p>Over 8.86 years median follow-up, 247 incident UC cases were recorded.