Mechanically Induced Sequential One-Pot Wittig Olefination–Diels-Alder Reaction: A Solvent-Free Approach to Complex Bicyclic Scaffolds

Furthermore, the extension of the sequence by a solvent-free one-pot oxidation is exemplified, achieving a three-step synthesis in a single milling vessel without intermediate workup and purification, which exhibits excellent green metrics in comparison with solution-based methods. This operationally simple and sustainable approach demonstrates the potential of mechanochemistry to streamline multistep organic synthesis, while reducing solvent use and energy demand.

The publication and its Supplementary Information can be found as open-access files on the publisher's website (see DOI). All files containing the analytical raw data for all compounds given in the Supplementary Information of the manuscript are uploaded. An additional file named RSC_Mechanochem_2025-compound_list.pdf is uploaded, that should clearly link the compound number given in the paper to the respective entry in the ELN (nbiederm) and the respective analytical data file.

Technical details The files uploaded contain the FIDs of NMR spectra recorded by an in-house Bruker Spectrometer. Standard software (such as MestreNova or Topspin ) is required to display NMR spectra.