DNA sequencing data for "Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis"

This dataset contains three types of DNA sequencing data. -Error-corrected DNA capture sequencing (ECTS) -Bulk whole-exome sequencing (WES) -Single-colony whole-genome sequencing (WGS) All sequencing was performed on an Illumina NovaSeq 6000 at the National Genomics Infrastructure in Stockholm, using paired-end sequencing mode. ECTS Bone marrow mononuclear cells isolated from all 93 healthy donors were subjected to ECTS for identification of somatic mutations targeted to 23 genes encompassing the most recurrently mutated genes reported in clonal hematopoiesis.

WES BM MNC DNA isolated from the first visit from 20 healthy donors above 71 years was subjected bulk WES. Paired buccal swab DNA was used for normal controls. Single colony WGS DNA extracted from 333 genotyped single colonies and 10 control buccal swabs from 10 donors was subjected to WGS.