Data Sheet 1_Association between atherogenic dyslipidemia and DBS-derived p-tau217 in older adults: evidence from SHARE DBS data.pdf

Background<p>Atherogenic dyslipidemia has been associated with adverse cognitive and dementia-related outcomes, but its relationship with Alzheimer’s disease-related blood biomarkers remains unclear.</p>Objective<p>To examine whether the atherogenic index of plasma (AIP) is associated with dried blood spot (DBS)-derived phosphorylated tau 217 (p-tau217) in older adults from Germany, Sweden, and Denmark.</p>Materials and methods<p>This cross-sectional analysis included adults aged ≥50 years from Germany, Sweden, and Denmark in the Survey of Health, Ageing and Retirement in Europe DBS biomarker substudy.

AIP was calculated as log10(triglycerides/high-density lipoprotein cholesterol). Multivariable linear regression with robust standard errors evaluated standardized natural log-transformed p-tau217, with additional dose–response analyses, comparisons across neurological biomarkers, and sensitivity analyses.</p>Results<p>Among 2,676 participants, a 1-SD higher AIP was associated with a 0.074-SD higher ln(p-tau217) (95% CI, 0.034–0.115; p < 0.001), corresponding after back-transformation to a 5.2% higher adjusted geometric mean DBS-derived p-tau217 concentration (95% CI, 2.3–8.1%).