<p>Proteinuria levels in curli-treated NZBxW/F1 and MRL/lpr mice.</p>

<p>Urine was collected weekly from (<b>A</b>) pre-onset and early-disease NZBxW/F1 (N = 16), (<b>B-C</b>) late-disease NZBxW/F1 (N = 27), or <b>(D)</b> MRL/lpr mice (N = 10) and assayed for protein levels in urine (proteinuria) by sulfosalicylic acid assay. <b>(C)</b> Comparison of the number of late-disease NZBxW/F1 mice that developed proteinuria ≥300 mg/dL over 6 weeks of treatment. Week -1 denotes baseline samples collected from each group one week before the first injection (Week 0).

Statistics: (<b>A-B, D</b>) Mixed effects analysis with Sidak’s multiple comparisons, comparisons within legend indicating overall column factor, <b>(C)</b> Chi-square contingency test (*p < 0.05).</p>