<b>Serum metabolites identification: characterizing the metabolic landscape</b>

However, the specific metabolic biomarkers indicative of prognosis in CC remains largely elusive. In this study, gas chromatography-mass spectrometry (GC-MS)-based metabolomics was employed to investigate metabolic alterations in 55 serum samples obtained from patients diagnosed with CC.

Our findings revealed that lipid and amino acid metabolism were significantly disturbed in the serum of CC patients, particularly in the biosynthesis of unsaturated fatty acids. 2-furoic acid, 2-aminoheptanedioic acid, 2,3-dihydroxybenzoic acid, and valproic acid were effective in distinguishing early-stage from late-stage CC patients. In patients who underwent radiotherapy, notable alterations in cadaverine, arachidonic acid, ethanolamine, 2-ethylhexanoic acid and oleic acid effectively differentiated those who received radiotherapy from those who did not.