Dataset and R code for deriving a composite FGF-based biomarker of cardiovascular risk in chronic kidney disease

Selected variables are first integrated into a continuous score, which is subsequently transformed into an ordinal variable to define groups of individuals with similar profiles, enabling classification into categories. The protocol supports downstream analyses to evaluate the association of this score and the derived groups with CKD stage and cardiovascular event-free survival.

This approach can be applied to similar settings in which multiple biomarkers are combined to characterize clinical phenotypes and assess their relationship with disease severity and clinical outcomes.</p>