Data · dataset · 2025
AMI-M1
Listed in Teesside University Research Data Repository
AML-M1 (Acute Myeloid Leukemia, French-American-British Classification M1) Definition: AML-M1 is a subtype of acute myeloid leukemia characterized by a proliferation of myeloblasts (immature white blood cells) with minimal maturation.
Description
It is classified under the FAB (French-American-British) system as M1, which means “without maturation.” Key Features: Bone marrow and blood contain ≥ 20% myeloblasts with minimal differentiation into mature cells.
Myeloblasts typically lack significant granulocytic maturation beyond the blast stage. Common markers: CD13, CD33 are usually positive, HLA-DR often positive. Clinical symptoms: fatigue, anemia, infections, bleeding tendencies due to bone marrow failure.
Read the rest (3 more)
Diagnosis: Bone marrow biopsy showing ≥ 20% myeloblasts. Immunophenotyping showing expression of myeloid markers such as CD13, CD33. Cytogenetic and molecular testing to identify mutations (e.g., FLT3, NPM1) that guide prognosis and treatment.
Treatment: Typically involves intensive chemotherapy aimed at inducing remission. May include consolidation chemotherapy and hematopoietic stem cell transplantation in eligible patients. Prognosis: Prognosis depends on various factors including genetic mutations, patient age, and response to treatment.
AML-M1 has a variable prognosis; patients with favorable mutations have better outcomes.
Links
Where it is published
- DOI doi.org/10.17632/3df2cj3v9z.2 ↗
DOI / persistent id · from researchdata tees ac uk
Catalogue records · 1
- OAI-PMH record data.mendeley.com/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Adata… ↗
metadata API · from researchdata tees ac uk
Topics
- From keywords
- Chemistry · Earth & Environmental Science · Engineering · Mathematics & Statistics · Medicine & Health
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Teesside University Research Data Repository | oai:data.mendeley.com/3df2cj3v9z.2 | 18 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| description | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| title | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/title |