Contrasting dermoscopic evolution of melanocytic lesions during anti–PD-1 therapy: nevus involution and incident melanoma

Sequential digital dermoscopy of a melanocytic nevus during nivolumab plus ipilimumab therapy: (A) baseline; (B) 1 year after treatment initiation, showing hypopigmentation, size reduction, and granularity, consistent with nevus involution; (C) 3 years after treatment initiation, showing almost complete disappearance of the nevus. Sequential digital dermoscopy of a melanoma that arose during nivolumab plus ipilimumab therapy: (D) baseline; (E) 10 months after treatment initiation, showing enlargement, granularity, negative network, and shiny white structures, suggestive of melanoma.