Data · dataset · 2026
Self-triggered smart biomaterials
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32641275.v1
Catheter-associated urinary tract infections (CAUTI) contribute a considerable logistical and economic burden on the healthcare system and is detrimental to patient quality of life.
Description
However, there is still a lack of effective methods to fully prevent and eradicate these infections, especially those caused by Proteus mirabilis which exacerbates the risk of catheter encrustation and blockage by increasing urinary pH during CAUTI development.
Therefore, there is a need for novel approaches to prevent or delay CAUTI and catheter encrustation. In this thesis, stimuli-responsive strategies were investigated as a potential solution. Firstly, free weak organic acids (WOAs) were shown to possess potential as anti-encrustation agents by counteracting <i>P. mirabilis</i>-induced urine alkalinisation which agreed with previous literature.
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However, this thesis, for the first time, synthesised a WOA-monomer conjugate which could be polymerised to form a hydrogel coating for controlled release of WOA in response to a rise in pH during CAUTI development. Later aspects of the thesis focused on improved use of antibiotics for the prevention of CAUTI. A pH-responsive hydrogel coating was developed for infection-responsive delivery of rifampicin which was shown to be able to provide on/off drug release in response to <i>P. mirabilis</i>.
Subsequent co-incorporation of hydrophobic ionic liquids with rifampicin enhanced the antibacterial efficacy. This approach offers a new avenue to provide long-term protection against CAUTI, as well as other medical device-associated infections.<br><br><i>Thesis is embargoed until 31 July 2028.</i>
Links
Where it is published
- DOI doi.org/10.17034/32641275.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
Provenance · 3 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32641275 | 6 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32641275 | 6 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32641275 | 6 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].anzsrc:field:400302 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Biomaterials'] |
| concepts[field].anzsrc:field:400302 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Biomaterials'] |
| concepts[field].anzsrc:field:400302 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Biomaterials'] |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |