Data · dataset · 2021
Plasma uptake of selected phenolic acids following New Zealand blackcurrant extract supplementation in humans raw data
Listed in Teesside University Research Data Repository
New Zealand blackcurrant (NZBC) extract is a rich source of anthocyanins and in order to exert health and/or physiological effects the anthocyanin-derived metabolites need to be bioavailable in vivo.
Description
We examined the plasma uptake of selected phenolic acids following NZBC extract supplementation alongside maintaining a habitual diet (i.e., not restricting habitual polyphenol intake). Twenty healthy volunteers (9 females), age: 28±7 years, height 1.73±0.09 m, body mass 73±11 kg) consumed a 300 mg NZBC extract capsule (CurraNZ™; anthocyanin content 105 mg) following an overnight fast.
Venous blood samples were taken pre and 1, 1.5, 2, 3, 4, 5, and 6 h post-ingestion of the capsule. Plasma concentrations of vanillic acid (VA), gallic acid (GA), and protocatechuic acid (PCA) were analysed by reversed-phase high-performance liquid chromatography (HPLC) and the HPLC analysis identified two dihydroxybenzoic (VA and PCA) and one trihydroxybenzoic acids (GA) in plasma following NZBC supplementation. Habitual anthocyanin intake was 168 (95%CI:68–404) mg⋅day-1 and no associations were observed between this and VA, PCA, and GA plasma uptake.
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Plasma time-concentration curves revealed that VA, GA, and PCA were most abundant at 3, 4, and 1.5 h post-ingestion, representing a 79%, 261% and 320% increase above baseline, respectively, with GA and PCA still elevated above pre at 6 h. This is the first study to demonstrate that an NZBC extract supplement increases the plasma uptake of phenolic acids VA, GA, and PCA even when a habitual diet is followed in the days preceding the experimental trial, although inter-individual variability is apparent.
Links
Where it is published
- DOI doi.org/10.17632/cf5m6v8w58.1 ↗
DOI / persistent id · from researchdata tees ac uk
Catalogue records · 1
- OAI-PMH record data.mendeley.com/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Adata… ↗
metadata API · from researchdata tees ac uk
Topics
- From keywords
- Earth & Environmental Science
Provenance · 1 source records, 6 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Teesside University Research Data Repository | oai:data.mendeley.com/cf5m6v8w58.1 | 16 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| description | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| title | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/title |