Performance of Covid-19 antigen rapid diagnostic tests for self-testing compared with antigen testing by professionals and molecular tests: A systematic review and meta-analysis [Research Data]

We searched multiple databases for articles evaluating the accuracy of COVID-19 self-testing or self-sampling through November 19th, 2021. Cohen’s kappa was estimated to as-sess concordance between self-testing/self-sampling and solely professional-use Ag-RDT results. Meta-analysis was performed to obtain pooled performance estimates compared to molecular testing.

The QUADAS-2 and GRADE tools were used to evaluate quality and cer-tainty of evidence. Results: Of 12,946 publications, 19 were eligible; two reported on self-testing, while 17 studies as-sessed self-sampling only. Risk of bias was low (28.1%).

Overall concordance with profes-sional-use Ag-RDTs (n=5) was high (kappa 0.92 [95% confidence interval (CI) 0.89 to 0.95]). Overall pooled sensitivity of Ag-RDT testing using self-testing/self-sampling was 72.0% (95% CI 62.4 to 80.0). Conclusion: COVID-19 self-testing/self-sampling exhibits reasonable performance and high concordance with professional-use Ag-RDTs.

This suggest that self-sampling, at a minimum, can be offered as part of COVID-19 testing strategies, despite high heterogeneity among studies and the paucity of data.