Data · dataset · 2026
Data sets for: Iterative Safe-by-Design Development of an Antibacterial Coating: Balancing Efficacy and Safety for Prosthetic Joint Infection Prevention
Listed in IISH Dataverse
An innovative coating combining polycationic poly-ε-lysine (PEL) and hyaluronic acid (HA) previously demonstrated promising in vitro results.
Description
However, subsequent in vivo results on antibacterial efficacy were inconsistent. Therefore, this study aimed to enhance the antibacterial efficacy of the coating by increasing PEL concentration twofold (from PEL-10 to PEL-20), elevating HA levels fivefold (from HA-1 to HA-5), and/or adding polyarginine (PAR30-4).
These four coating formulations underwent in vitro safety and antibacterial efficacy assessments based on Safe-by-Design (SbD) principles. In vitro testing included bacterial adhesion, osteoblast behavior, and immune response evaluations.
Links
Where it is published
- Dataverse dataset page dataverse.nl/dataset.xhtml?persistentId=doi%3A10.34894%2FQTX77O ↗
landing page · from datasets iisg amsterdam
- DOI doi.org/10.34894/qtx77o ↗
DOI / persistent id · from datasets iisg amsterdam
Catalogue records · 1
- Dataverse API dataverse.nl/api/datasets/:persistentId/?persistentId=doi%3A10.34894%2FQTX7… ↗
metadata API · from datasets iisg amsterdam
Topics
- Stated by source
- Medicine, Health and Life Sciences
- From keywords
- Life Sciences · Medicine & Health
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| IISH Dataverse | doi:10.34894/QTX77O | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].dataverse_subject:medicine-health-and-life-sciences | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /subjects |
| concepts[field].local:field:life-sciences | mapping · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /subjects |
| concepts[field].local:field:medicine-health | mapping · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /subjects |
| created_date | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | |
| description | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /description |
| publication_date | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | |
| title | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /name |
| updated_date | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | |
| version_label | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 |